Copathology infuences of clinical phenotype Lead Investigator: Corey McMillan Institution : University of Pennsylvania E-Mail : mcmillac@upenn.edu Proposal ID : 756 Proposal Description: The overall goal of this project is to evaluate the influence of alpha-synuclein and TDP-43 pathology on clinical phenotype of Alzheimer's disease. 1 - Does co-pathology influence rate of cognitive decline? 2 - Does co-pathology influence non-cognitive features?